Histone deacetylase inhibitors and methods of use thereof

Details Histone deacetylase inhibitors and methods of use thereof Histone deacetylase inhibitors and methods of use thereof

C - Chemistry, Metallurgy

07

C

C07C 259/04 (2006.01) A01N 37/10 (2006.01) A01N 43/40 (2006.01) A01N 43/42 (2006.01)

Patent

CA 2531661

One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.

L'invention concerne, dans un aspect, des inhibiteurs de HDAC. Elle concerne également des procédés de sensibilisation d'une cellule cancéreuse aux effets cytotoxiques de la radiothérapie. Elle concerne en outre des procédés permettant de traiter des cancers ainsi que des maladies neurologiques. De plus, l'invention concerne des compositions pharmaceutiques comprenant ledit inhibiteur de HDAC, ainsi que des trousses comprenant un récipient contenant un tel inhibiteur de HDAC.

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