Modified factor vii

Details Modified factor vii Modified factor vii

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2103546

The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagula- tion cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical com- positions of the modified Factor VII are used to treat a variety of coagulation-related disorders.

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