C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 335/04 (2006.01) A61K 31/38 (2006.01) A61K 31/382 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 333/50 (2006.01) C07D 337/00 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2232355
The present invention relates to morphinan derivatives that are neuroprotective against excitatory amino acid (EAA) cytotoxicity. In particular, morphinan derivatives of the invention act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor and are useful as protective agents against peripheral and central nervous system NMDA-receptor mediated toxicity and convulsions.
L'invention concerne des dérivés de morphinane exerçant une activité neuroprotectrice contre la cytotoxicité d'acides aminés excitants (EAA). Ces dérivés de morphinane agissent, en particulier, en tant qu'antagonistes au niveau du récepteur ionotrope de NMDA (acide N-méthyle-D-aspartique) et sont utiles en tant qu'agents protecteurs contre les convulsions et la toxicité provoquées par le récepteur de NMDA du système nerveux central et périphérique.
Biochem Pharma Inc.
Borden Ladner Gervais Llp
LandOfFree
Thiamorphinans with neuroprotective activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thiamorphinans with neuroprotective activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiamorphinans with neuroprotective activity will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2080091