C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2455915
Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
L'invention concerne des méthodes et des compositions permettant d'utiliser le polypeptide à chaîne invariant de classe II MHC, Ii (également connu comme CD74), en tant que récepteur du facteur d'inhibition de la migration des macrophages (MIF). Celles-ci comprennent des méthodes et des compositions permettant d'utiliser ce récepteur, ainsi que des agonistes et des antagonistes du MIF se fixant à ce récepteur, ou modulant l'interaction du MIF avec CD74 ou les conséquences d'une telle interaction, dans le traitement d'états pathologiques se caractérisant par des niveaux de MIF modifiés localement ou systémiquement, en particulier les états inflammatoires et le cancer.
Bucala Richard J.
Leng Lin
Metz Christine N.
Baxter Healthcare Sa
Baxter International Inc.
Cytokine Pharmasciences Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Methods and compositions for using mhc class ii invariant... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for using mhc class ii invariant..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for using mhc class ii invariant... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2080993