Topical bisphosphonates for prevention of bone resorption

Details Topical bisphosphonates for prevention of bone resorption Topical bisphosphonates for prevention of bone resorption

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/12 (2006.01)

Patent

CA 2245793

Bisphosphonates inhibit bone resorption associated with periodonatal or orthopedic surgery when applied topically to the bone. A novel formulation for topical application contains a gelatin matrix which is soaked in a solution containing a bone absorption inhibiting effective amount of a bisphosphonate or a pharmaceutically acceptable salt.

Cette invention concerne des bisphosphonates utilisés en chirurgie périodontale ou orthopédique, et permettant de prévenir la résorption osseuse lorsqu'ils sont appliqués de manière topique sur l'os. Une nouvelle formulation pour application topique comprend une matrice de gélatine qui est trempée dans une solution contenant une quantité suffisante pour inhiber l'absorption osseuse d'un bisphosphonate ou de l'un de ses sels acceptables sur le plan pharmaceutique.

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