A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/765 (2006.01) A61K 31/19 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2383011
Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compo-sitions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, se-dation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.
L'invention concerne des compositions oligomères et polymères à base de GHB et produisant cette substance après administration <i>in vivo</i>. L'invention concerne également des dispositifs pour le stockage et la délivrance des compositions, qui sont utiles dans une variété d'applications, par exemple: narcolepsie, schizophrénie chronique, schizophrénie catatonique, psychoses atypiques, syndrome cérébral chronique, névrose, alcoolisme, narcomanie et sevrage de drogue, maladie de Parkinson et autres maladies neuropharmacologiques, hypertension, ischémie, collapsus circulatoire, exposition aux rayonnements, cancer, et infarctus du myocarde. On peut citer les autres applications suivantes : induction de l'anesthésie, utilisation sédative, production d'hormone de croissance, renforcement du désir sexuel, effets anorexigènes, euphorie, relaxation des muscles lisses, production de masse musculaire, et sommeil, y compris les mouvements oculaires rapides. Selon une variante, les compositions peuvent être utilisées pour engendrer des absences.
Martin David P.
Williams Simon F.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Metabolix Inc.
Tepha Inc.
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