Cationic amphiphiles

Details Cationic amphiphiles Cationic amphiphiles

C - Chemistry, Metallurgy

07

F

C07F 9/10 (2006.01) A61K 9/127 (2006.01) A61K 47/24 (2006.01) C07J 9/00 (2006.01)

Patent

CA 2194221

Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The amphiphiles can be used as carriers for delivering macromolecules intracellularly.

Cette invention concerne des amphiphiles cationiques qui sont des esters d'alkyle ou d'alcoxyalkyle O-phosphate de composés zwittérioniques de diacylphosphatidyle tels que le phosphatidylcholine ou le phosphatidyle éthanolamine. Ces amphiphiles peuvent être utilisés comme véhicules pour transporter des macromolécules à l'intérieur des cellules.

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