Cyclin dependent kinase inhibitors and methods of use

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/18 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61P 1/00 (2006.01) A61P 37/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2761896

The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.

La présente invention concerne des procédés et des compositions permettant de protéger des cellules saines contre les lésions provoquées par des agents dégradant l'ADN. L'invention concerne, en particulier, l'action protectrice d'inhibiteurs sélectifs des kinases cycline-dépendantes 4/6 (CDK4/6), administrés à des sujets ayant été exposés à une dégradation de leur ADN ou susceptibles de l'être.

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