A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2637786
The present invention relates PirB expression and function in nervous tissue. PirB expressed in neurons acts to restrict plasticity of neural circuits, and/or, restrict competition between circuits with different activity patterns or levels, for cortical representation. Thus, the present invention relates to methods of increasing nervous system plasticity and associated disorders and diseases in a subject comprising administering to the subject an agent which modulates the activity, signal transduction or expression of PirB in neurons of the subject.
La présente invention concerne l'expression et la fonction du PirB dans un tissu nerveux. Le PirB exprimé dans les neurones agit en vue de restreindre la plasticité des circuits neuronaux et/ou restreindre la compétition entre les circuits comprenant différents modèles ou niveaux d'activité pour la représentation corticale. Ainsi, la présente invention se rapporte à des procédés, destinés à accroître la plasticité du système nerveux et traiter des troubles et des maladies associés à la plasticité neuronale chez un sujet, qui consistent à administrer au sujet un agent qui module l'activité, la transduction du signal ou l'expression du PirB dans les neurones du sujet.
Shatz Carla
Syken Joshua
Osler Hoskin & Harcourt Llp
President And Fellows Of Harvard College
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