Tranilast-containing preparation for external application...

Details Tranilast-containing preparation for external application... Tranilast-containing preparation for external application...

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 9/06 (2006.01) A61K 9/70 (2006.01) A61K 47/16 (2006.01) A61K 47/22 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2244679

An external preparation containing tranilast which is excellent in the release of the active ingredient contained therein, achieves a high percutaneous absorption, fully ensures the effective drug concentration in the skin tissue and little irritates the skin. This preparation is composed of an aqueous base containing as the active ingredient tranilast, its salt or a mixture thereof. The aqueous base contains a solubilizer for tranilast, a dispersant, an absorption aid, an adhesive and/or a shape retenting agent, and water. The active ingredient has been solubilized by the above-mentioned solubilizer and dispersed in the aqueous base by the above- mentioned dispersant.

Cette invention concerne une composition à usage externe contenant du tranilast, laquelle possède d'excellentes qualités de libération du principe actif qu'elle contient, permet d'obtenir une absorption percutanée élevée, et assure pleinement une concentration efficace du médicament dans les tissus de la peau sans entraîner de trop grande irritation de cette dernière. Cette préparation se compose d'une base aqueuse qui comprend, en qualité de principe actif, du tranilast, un sel de celui-ci ou un mélange de ces derniers. Cette base aqueuse contient également un agent de solubilisation du tranilast, un agent de dispersion, un agent d'aide à l'absoprtion, un adhésif et/ou un agent de maintien de la forme et, enfin, de l'eau. Le principe actif est solubilisé à l'aide de l'agent de solubilisation susmentionné, puis dispersé dans la base aqueuse à l'aide dudit agent de dispersion.

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