C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2646166
The invention relates to 3-substituted N-(aryl- or heteroaryl)-pyrazolo[1 ,5-a]pyrimidine compounds, their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warmblooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase, especially tie-2 kinase, activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.
L'invention concerne des composés N-(aryl- ou hétéroaryl)-pyrazolo[1,5-a]pyrimidines substitués en position 3, l'utilisation de ceux-ci en tant qu'inhibiteurs de kinases, de nouvelles formulations pharmaceutiques comprenant lesdits composés, lesdits composés destinés à être utilisés dans le diagnostic ou le traitement thérapeutique d'animaux à sang chaud, en particulier de l'homme, l'utilisation de ceux-ci dans le traitement de maladies ou pour la fabrication de formulations pharmaceutiques utiles dans le traitement de maladies qui répondent à la modulation de l'activité de kinases, en particulier de la kinase Tie2, des procédés de traitement consistant à administrer lesdits composés à un animal à sang chaud, en particulier l'homme, et des procédés pour la fabrication desdits composés.
Furet Pascal
Imbach Patricia
Masuya Keiichi
Vaupel Andrea
Fetherstonhaugh & Co.
Novartis Ag
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