Solid preparation comprising alogliptin and metformin...

Details Solid preparation comprising alogliptin and metformin... Solid preparation comprising alogliptin and metformin...

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 31/155 (2006.01) A61K 31/513 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2694620

The present invention provides a solid preparation containing compound (I) [compound (I) is as defined in the specification] or a salt thereof, and metformin hydrochloride, which is useful as a therapeutic drug for diabetes and the like, and superior in the preservation stability. A solid preparation having a first part and a second part:a first part: a part containing compound (I) or a salt thereof and substantially free of metformin hydrochloride a second part: a part containing metformin hydrochloride and substantially free of compound (I) and a salt thereof.

L'invention concerne une préparation solide contenant un composé (I) [le composé (I) est tel que défini dans la description] ou un sel de celui-ci et de l'hydrochlorure de metformine. Cette préparation est utile en tant que médicament contre le diabète et analogue et présente une stabilité de conservation supérieure. La préparation selon l'invention est constituée d'une première et d'une deuxième partie : la première partie contenant le composé (I) ou un sel de celui-ci, ladite partie étant sensiblement exempte d'hydrochlorure de metformine ; et une deuxième partie contenant de l'hydrochlorure de metformine, ladite partie étant sensiblement exempte du composé (I) et d'un sel de celui-ci.

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