Compositions and methods for inhibition of hiv

Details Compositions and methods for inhibition of hiv Compositions and methods for inhibition of hiv

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 31/18 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2695337

Described are methods and compositions for preventing and/or treating HIV infection, as well as in vitro and in vivo methods of inhibiting HIV replication, inhibiting HIV viral transcription, inhibiting the viral Tat protein, and inhibiting HIV LTR expression. The methods involve administering a TOE1 polypeptide, fragment or deletion mutant thereof, either to a subject in need of treatment or to a cell infected with an HIV virus. Compositions may comprise the described polypeptide, or a polynucleotide encoding same.

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