Methods and compositions for amplifying a detectable signal

Details Methods and compositions for amplifying a detectable signal Methods and compositions for amplifying a detectable signal

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2705984

Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.

L'invention concerne des procédés et des matériaux associés à un procédé amélioré d'amplification d'un signal dans un test diagnostique sur un acide nucléique, comprenant les étapes consistant à fournir un polymère d'amplification lié à un analyte acide nucléique, le polymère d'amplification comprenant une pluralité de groupes amine ; à lier les groupes amine sur le polymère d'amplification avec un complexe marqueur détectable ; et à faire réagir dans des conditions de concentration élevée en sel un composé acylant avec les groupes amine non liés à un complexe marqueur détectable.

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