C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2142181
A DNA sequence (-426 to +28 base pairs) cloned from the probasin (PB) gene promoter region confers androgen regula- tion in cell culture and prostate specific expression in transgenic non-human eukaryotic animals. Various PB promoter fragments impart preferential regulation by androgens compared to other steroid hormones on fused transgenes. Alteration of the DNA se- quences and/or combinations permits production of an (1) assay for androgenic or anti-androgenic materials, (2) transgenic non- human eukaryotic animals models for prostatic disease, (3) cell culture models for prostatic disease, and (4) treatment of human benign prostatic hyperplasia and human prostate cancer by gene therapy. This invention permits assays on agonist and antagon- ist of the androgen receptor or pathways that result in androgen action, testing materials for carcinogenicity of the prostate, test- ing drugs and gene therapy, or protection potential of materials on prostatic cells against prostatic disease.
Sim & Mcburney
University Of Manitoba
LandOfFree
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