Chimeric molecules to modulate gene expression

Details Chimeric molecules to modulate gene expression Chimeric molecules to modulate gene expression

C - Chemistry, Metallurgy

07

K

C07K 17/10 (2006.01) C07K 17/02 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2437942

The present invention provides a chimeric molecule including a base-pairing segment that binds specifically to a single-stranded nucleic acid molecule; and a moiety that modulates splicing or translation. The invention also provides a chimeric molecule including a base-pairing segment that binds specifically to a double-stranded nucleic acid molecule; and a peptide that modulates transcription, wherein the peptide comprises up to about one hundred amino acid residues.

L'invention concerne une molécule chimère comprenant un segment d'appariement de bases se fixant de façon spécifique à une molécule d'acide nucléique monocaténaire, ainsi qu'une fraction modulant l'épissage ou la traduction. Elle concerne également une molécule chimère comprenant un segment d'appariement de bases se fixant de façon spécifique à une molécule d'acide nucléique bicaténaire, et un peptide modulant la transcription et composé de 100 résidus aminoacides maximum.

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