C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2595038
The present invention provides for a modified TIE-2 ligand which has been altered by addition, deletion or substitution of one or more amino acids, or by way of tagging, with for example, the Fc portion of human IgG-1, but which retains its ability to bind the TIE-2 receptor. The invention further provides,for a modified TIE- 2 ligand which is a chimeric TIE-2 ligand comprising at least a portion of a first TIE- 2 ligand and a portion of a second TIE-2 ligand which is different from the first. In a specific embodiment, the invention further provides for a chimeric TIE ligand comprising at least a portion of TIE-2 ligand-1 and a portion of TIE-2 ligand-2. In addition the present invention provides for isolated nucleic acid molecule encoding the modified TIE-2 ligands described The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
Davis Samuel
Yancopoulos George D.
Osler Hoskin & Harcourt Llp
Regeneron Pharmaceuticals Inc.
LandOfFree
Modified tie-2 receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified tie-2 receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified tie-2 receptor ligands will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2085252