Peptides with sulphate ester groups

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

530/7.06, 530/7.

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/595 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2026005

2026005 9008773 PCTABS00001 There are disclosed compounds of formula (I): Q-T-M-G-W-X-J-P-Z, wherein Q represents H-asp, H-.beta.Asp, H-DAsp, For, Suc or R1R2CHOCO, T represents Tyr(SO3H), M represents Ile, G represents Gly, D-Ala or Pro, W represents Trp, X represents Ahx, J represents Asp, P represents MePhe, Z represents NR3R4, R1, R2, R3 and R4 are independently H or lower alkyl, in addition a) Q and T may together represent Hpp(SO3H), b) when Q represents H-.beta.Asp, X may represent Ile, c) when G represents D-Ala, M and X may both represent Met, d) when Q represents H-DAsp, then M and X may both represent Ile provided that P represents Phe, e) when Q represents H-Asp and G represents Pro, M and X may both represent Met, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment of obesity.

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