Process for estimating random error in chemical and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/00 (2006.01) A01K 67/027 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2421293

A method is disclosed for improving the reliability of physical measurements obtained from array hybridization studies performed on an array having a large number of genomic samples including a replicate subset containing a small number of replicates insufficient for making precise and valid statistical inferences. An error in measurement of a sample is estimated by combining estimates obtained with individual samples in the replicate subset, and utilizing the estimated sample error as a standard for accepting or rejecting the measurement of a sample under test.

L'invention concerne un procédé destiné à améliorer la fiabilité de mesures physiques obtenues à partir d'études d'hybridation de réseaux effectuées sur un réseau regroupant un grand nombre d'échantillons génomiques comportant un sous-ensemble répété, ledit sous-ensemble contenant un nombre réduit d'échantillons répétés se révélant insuffisant pour effectuer des inférences statistiques précises et valables. Une erreur dans la mesure d'un échantillon est évaluée par combinaison d'estimations obtenues avec des échantillons individuels dans le sous-ensemble répété, et par utilisation de l'erreur d'échantillon évaluée en tant que standard pour la validation ou le rejet de la mesure d'un échantillon à tester.

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