Peptides and processes for producing cyclic peptides

Details Peptides and processes for producing cyclic peptides Peptides and processes for producing cyclic peptides

C - Chemistry, Metallurgy

07

K

C07K 14/585 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2045495

- 80 - ABSTRACT In this invention, a peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. Image (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr; X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide). The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.

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