Therapeutic use of acetazolamide for the treatment of brain...

A - Human Necessities – 61 – K

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A61K 31/425 (2006.01) A61K 31/00 (2006.01) A61K 31/433 (2006.01)

Patent

CA 2196873

A method for treating victims of cerebral edema is presented that includes the intravenous injection of acetazolamide (A.K.A., DIAMOX), which is a readily- available and often-prescribed diuretic. Such edema, or brain swelling may be caused as a result of ischemic strokes especially, but also swelling due to tumors, surgeries, or cerebral trauma. It is preferred to combine the acetazolamide therapy with hyperventilation of the lungs, even including the use of supplemental oxygen, thereby to reduce the concentration of carbon dioxide in the blood and hence in the brain.

L'invention concerne une méthode de traitement de sujets atteints d'oedème cérébral, selon laquelle on effectue une injection intraveineuse d'acétazolamide (A.K.A., DIAMOX?) qui est un diurétique facilement disponible et souvent prescrit. Un tel oedème, ou gonflement cérébral, peut survenir plus particulièrement à la suite d'un accès ischémique, mais également, d'un gonflement dû à des tumeurs, des opérations chirurgicales ou des traumatismes cérébraux. La thérapie à l'acétazolamide est de préférence combinée à une hyperventilation des poumons, y compris même à l'utilisation d'oxygène supplémentaire, ce qui permet de réduire la concentration du dioxyde de carbone dans le sang et, par conséquent, dans le cerveau.

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