Vaccines

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/01 (2006.01) A61K 39/295 (2006.01) C07K 14/075 (2006.01) C07K 14/145 (2006.01) C12N 15/35 (2006.01) C12N 15/47 (2006.01) C12N 15/48 (2006.01) C12N 15/861 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2074502

A recombinant adenovirus acting as a vector for an antigen-producing gene (e.g. a rabies glycoprotein gene) comprises a CAV-2 strain modified to contain the promoter-gene sequence within the region from the SmaI site close to the end of the invert- ed terminal repeat up to the promoter for the early region 4 (E4). To assist replication the recombinant virus is transfected into a cell line expressing Ela proteins. The recombinant virus is used for the production of a corresponding vaccine.

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