C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2386415
The invention relates to lymphocytes, having the property of recognizing cells of a patient in which the pericellular membrane expression of HSP or presentation of HSP epitopes has been induced and increased with respect to the normally occuring HSP expression level in the patient's body, and corresponding to an overexpression of HSP, particularly at a level of at least about 10 times the normally occuring level. These lymphocytes are used, for instance, as active substance in pharmaceutical compositions.
L'invention concerne des lymphocytes présentant la caractéristique de reconnaître des cellules d'un patient dans lesquelles l'expression de la membrane péricellulaire de la protéine du stress ou la présentation des épitopes de la protéine du stress a été induite et renforcée par rapport au niveau normal d'expression de la protéine du stress dans le corps d'un patient; ce qui correspond à une surexpression de la protéine du stress, en particulier, à un niveau environ dix fois supérieur au niveau normal. ces lymphocytes sont utilisés, par exemple, comme substance active dans des compositions pharmaceutiques.
Abastado Jean Pierre
Bartholeyns Jacques
Fetherstonhaugh & Co.
I.d.m. Immuno-Designed Molecules
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