Peripheralization of hematopoietic stem cells

Details Peripheralization of hematopoietic stem cells Peripheralization of hematopoietic stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/0789 (2010.01) C12N 5/071 (2010.01) A61K 31/505 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/19 (2006.01) A61K 38/39 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2148712

2148712 9411027 PCTABS00032 The invention provides methods for peripheralizing CD34+ cells, including hematopoietic stem cells. In a first aspect, the method comprises the step of administering a blocking agent of VLA-4 antigen on the surface of CD34+ cells. In a second aspect, the method comprises administering a blocking agent of VLA-4 antigen on the surface of CD34+ cells and administering a stimulating agent of CD34+ cell proliferation in vivo. The method according to the invention is useful in the treatment of cancer or AIDS, and in gene therapy.

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