Use of inhibitors of protein kinase c epsilon to treat pain

Details Use of inhibitors of protein kinase c epsilon to treat pain Use of inhibitors of protein kinase c epsilon to treat pain

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/55 (2006.01) A61K 45/00 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2336709

The role of .epsilon. isozyme of protein kinase C ("PKC.epsilon.") in pain perception, particularly hyperalgesia, methods of lessening pain through administration of inhibitors of PKC.epsilon., methods of identifying compounds that modulate pain, uses of inhibitors of PKC.epsilon. in the preparation of a medicament for the treatment of pain, and pharmaceutical compositions comprising an inhibitor of PKC.epsilon. and PKC.epsilon.-independent analgesic agent are disclosed.

L'invention porte sur le rôle joué par l'isozyme .epsilon. de la protéine kinase C ("PKC.epsilon.") dans la perception de la douleur, notamment l'hyperalgie, sur des procédés d'atténuation de la douleur par administration d'inhibiteurs de PKC.epsilon., sur des procédés d'identification de composés qui modulent la douleur, sur les utilisations des inhibiteurs de PKC.epsilon. dans la préparation d'un médicament destiné au traitement de la douleur, et sur des compositions pharmaceutiques comprenant un inhibiteur de PKC.epsilon. et un agent analgésique indépendant de PKC.epsilon..

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