Heteroaryloxy nitrogenous saturated heterocyclic derivative

Details Heteroaryloxy nitrogenous saturated heterocyclic derivative Heteroaryloxy nitrogenous saturated heterocyclic derivative

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4545 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 1/16 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) A61P 19/06 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) A61P 25/32

Patent

CA 2529790

Compound of the formula: (I) [wherein each of X1, X2 and X3 independently represents N or CH, W represents the formula (II): (II) or the formula (III): (III) and Y represents a group of the formula (IV): (IV) ], or a pharmacologically acceptable salt thereof. This compound exhibits histamine receptor H3 antagonist or inverse agonist activity and is useful for the treatment and/or prevention of obesity, diabetes, hormonal secretion abnormality, sleep disorder, etc.

L'invention concerne des composés de formule (I), dans laquelle X?1¿, X?2¿, X?3¿ représentent indépendamment les uns des autres N ou CH, w représente la formule (II), ou la formule (III), et Y représente un groupe de formule (IV). L'invention concerne également un sel pharmaceutiquement acceptable des composés. Les composés de l'invention présentent une activité d'antagoniste du récepteur H3 de l'histamine ou une activité agoniste inversée et ils sont utilisés dans le traitement et/ou la prévention de l'obésité, du diabète, d'un dysfonctionnement des sécrétions hormonales, des troubles du sommeil, etc.

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