Protein specific to pancreatic beta cells in islets of...

Details Protein specific to pancreatic beta cells in islets of... Protein specific to pancreatic beta cells in islets of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2506331

The invention relates to protein ZnT-8 which is specifically expressed in the pancreatic beta cells in islets of Langerhans, to a polynucleotide encoding said protein which is involved in the maturation and exocytosis of insulin, and to the applications thereof, for example, for sorting and studying beta cells and for screening medicine acting on diabetes and hyperinsulinism.

Protéine dénommée ZnT-8, exprimée de manière spécifique dans les cellules pancréatiques bêta des îlots de Langerhans, polynucléotide codant ladite protéine qui est impliquée dans la maturation et l'exocytose de l'insuline, et leurs applications notamment pour le tri et l'étude des cellules bêta, ainsi que pour le criblage de médicaments actifs sur le diabète et l'hyperinsulinisme.

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