Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine...

Details Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine... Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine...

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/505 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2563635

Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.

La présente invention concerne des composés représentés par la formule structurelle (I) ou certains de leurs sels pharmaceutiquement admis. Dans cette formule, R est phényle éventuellement substitué, furanyle, thiényle, pyridyle, N-oxyde de pyridyle, oxazolyle ou pyrrolyle, ou cycloalcényle. R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont H, alkyle ou alcoxyalkyle. Enfin, Z est aryle éventuellement substitué ou hétéroaryle. L'invention concerne également l'utilisation de composés de la formule (I) pour le traitement de maladies du système nerveux central, en particulier la maladie de Parkinson, seuls ou associés à d'autres agents destinés au traitement de la maladie de Parkinson. L'invention concerne enfin des compositions pharmaceutiques comprenant ces composés.

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