Improved stable coagulation controls

G - Physics – 01 – N

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G01N 33/96 (2006.01) A61K 35/16 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2021581

Improved stable coagulation control plasmas are described which contain blood plasma, and effective amounts of (a) a buffer to maintain a physiological pH, (b) a protease inhibitor, and (c) a suitable stabilizing carbohydrate. Preferred control plasmas also contain thimerosal and/or sodium azide. Also described are stable control plasmas having high levels of Factor V and VIII including plasma from blood which has been collected directly from an animal source into a solution containing (a) a buffer to maintain a physiological pH, (b) a protease inhibitor, and (c) citrate, and to which, after removal of red blood cells, has been added at least about 2 weight percent of a suitable stabilizing carbohydrate, such as sucrose. Methods for preparing stable control plasmas are also described.

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