Microbial transformation process for antihypertensive products

Details Microbial transformation process for antihypertensive products Microbial transformation process for antihypertensive products

C - Chemistry, Metallurgy

12

P

C12P 19/28 (2006.01) C07D 471/04 (2006.01) C07H 19/056 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2047029

12/CSQ2 18157 TITLE OF THE INVENTION MICROBIAL TRANSFORMATION PROCESS FOR ANTIHYPERTENSIVE PRODUCTS ABSTRACT OF THE DISCLOSURE Fermentation of the microorganism Streptomyces sp. MA6751 (ATCC No. 55043) in the presence of the Angiotensin II (A II) receptor antagonist Image (II) 12/CSQ2 - i - 18157 yields an N2-tetrazole .beta.-glucuronide analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

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