C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2118309
Lymphocyte activation antigen HB15, and the human cDNA and gene sequences encoding HB15, are disclosed. HB15 is not expressed at detectable levels by circulating leukocytes but has a unique pattern of expression among tissues. HB15 is uniquely expressed by Langerhan's cells within the skin and other subpopulations of dendritic cells. Also disclosed are antibodies reactive with HB15 and methods of using anti-HB15 antibodies, or other antagonists to HB15 function, to treat an immunological disorder, disease or syndrome.
Sont décrits l'antigène HB15 d'activation lymphocytaire ainsi que les séquences d'ADNc et de gènes humains encodant cet antigène. L'HB15 n'est pas exprimé, à des niveaux détectables, par des leucocytes en circulation mais présente une forme unique d'expression parmi les tissus. L'HB15 est uniquement exprimé par les cellules de Langerhan au sein de la peau et par d'autres sous-populations de cellules dendritiques. Sont également décrits des anticorps réactifs avec l'HB15 et des procédés d'utilisation d'anticorps anti-HB15, ou bien d'autres antagonistes de la fonction HB15, pour traiter un dérèglement, une maladie ou un syndrome immunologiques.
Tedder Thomas F.
Zhou Liang-Ji
Dana-Farber Cancer Institute Inc.
Ridout & Maybee Llp
LandOfFree
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