Transgenic animals and methods of making recombinant antibodies

Details Transgenic animals and methods of making recombinant antibodies Transgenic animals and methods of making recombinant antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2604440

The present invention concerns a means for obtaining cells which produce human, humanized or chimeric antibodies in commercially useful quantities. The invention permits high antibody producer cells to be selected and isolated from animals for use in culture to produce antibodies. The invention also provides methods for the affinity maturation of human, humanized or chimeric immunoglobulins.

L'invention concerne un moyen permettant d'obtenir des cellules produisant des anticorps humains, humanisés ou chimériques dans des quantités commercialement utiles. L'invention permet également de sélectionner et d'isoler à partir d'animaux des cellules produisant une grande quantité d'anticorps, destinées à être utilisées en culture pour produire des anticorps. L'invention concerne également des procédés de maturation de l'affinité d'immunoglobulines humaines, humanisées ou chimériques.

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