A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2260845
An oral preparation contains in a matrix capable of swelling in an aqueous medium at least one active pharmaceutical substance which is released in the aqueous medium when the matrix swells therein, in a retarded manner, while the matrix is largely resistant to decomposition during the release process. The preparation is characterised in that it consists of a stratified tablet with layers which adhere onto each other and of which at least one layer is the swellable matrix layer and at least another layer is an auxiliary and/or substrate layer. The swellable matrix layer contains a certain proportion of cross-linked amylose.
Préparation orale renfermant, dans une matrice capable de gonflement dans un milieu aqueux, au moins une substance active pharmaceutique, laquelle est libérée avec retard, lors de ce gonflement, dans le milieu aqueux, ladite matrice demeurant largement résistante à la dégradation, caractérisée en ce qu'elle est constituée par un comprimé stratifié présentant des couches superposées adhérant entre elles, dont au moins une couche est la couche de matrice capable de gonflement, et au moins une autre couche est une couche auxiliaire et/ou une couche support, et en ce que la couche de matrice capable de gonflement renferme une fraction d'amylose réticulée transversalement.
Blake Cassels & Graydon Llp
Lts Lohmann Therapie-Systeme Ag
Lts Lohmann Therapie-Systeme Gmbh
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