Solid pharmaceutical dosage form

Details Solid pharmaceutical dosage form Solid pharmaceutical dosage form

A - Human Necessities

61

K

A61K 31/00 (2006.01)

Patent

CA 2536638

A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water- soluble polymer having a Tg of at least about 50 ~C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.

L'invention concerne une forme posologique pharmaceutique solide qui confère une meilleure biodisponibilité orale aux inhibiteurs de la protéase du VIH. D'une manière plus spécifique, cette forme posologique contient une dispersion solide d'au moins un inhibiteur de la protéase du VIH dans au moins un polymère pharmaceutiquement acceptable soluble dans l'eau et au moins un tensioactif pharmaceutiquement acceptable, le polymère pharmaceutiquement acceptable soluble dans l'eau présentant un Tg d'au moins environ 50 ·C. De préférence, le tensioactif pharmaceutiquement acceptable possède une valeur HLB comprise entre environ 4 et environ 10.

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