Phosphite dehydrogenase mutants for nicotinamide cofactor...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/02 (2006.01)

Patent

CA 2529063

Phosphite dehydrogenase mutant enzymes were generated that provide relaxed cofactor specificity and increased thermostability over the wild type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.

L'invention concerne l'obtention d'enzymes mutantes de phosphite déshydrogénase qui présentent une spécificité de cofacteur déroulé et une thermostabilité accrue par rapport à l'enzyme du type sauvage. Les enzymes mutantes sont utilisées pour la régénération du cofacteur du nicotinamide.

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