Integrin receptor antagonists

Details Integrin receptor antagonists Integrin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 223/20 (2006.01) A61K 31/55 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2304117

This invention relates to the seven membered at least one nitrogen containing tricyclic heterocyclic pharmaceutically active compounds which bind to integrins, such as the vitronectin receptor and fibrinogen receptor. Such compounds are useful for inhibiting platelet aggregation and osteoclast attachment to bone.

L'invention se rapporte à des composés à sept éléments, pharmaceutiquement actifs, hétérocycliques, tricycliques, contenant au moins un azote, qui se lient aux intégrines, tels que le récepteur de vitronectine et le récepteur du fibrinogène. Ces composés s'avèrent utiles s'agissant d'inhiber l'agrégation plaquettaire et la fixation des ostéoclastes à l'os.

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