Human ice homolog

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/57 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2222752

The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for antisense molecules to the nucleotide sequences which encode ICEY, expression vectors for the production of purified ICEY, antibodies capable of binding specifically to ICEY, hybridization probes or oligonucleotides for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for activation of monocyte/macrophages based on ICEY- encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.

L'invention concerne des séquences nucléotidiques et d'acides aminés qui identifient et codent un nouvel homologue de l'enzyme de conversion de l'interleukine 1 (ICEY). Elle porte aussi sur des molécules antisens dirigées contre les séquences nucléotidiques qui codent ICEY, sur des vecteurs d'expression pour la production d'ICEY purifiée, sur des anticorps capables de se fixer spécifiquement à ICEY, sur des sondes d'hybridation ou des oligonucléotides pour la détection de séquences nucléotidiques codant ICEY, sur des cellules hôtes manipulées génétiquement pour l'expression d'ICEY, sur des essais diagnostiques pour l'activation de monocytes/macrophages basés sur des molécules d'acide nucléique codant ICEY, sur l'utilisation de la protéine pour la production d'anticorps capables de se fixer spécifiquement à la protéine et sur l'utilisation de la protéine pour cribler des inhibiteurs.

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