C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2428438
The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell division and proliferation processes that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologues of said genes including all biologically-active derivatives thereof. The invention further relates to the use of said gene products (including said orthologues) in the development or isolation of anti- proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative diseases.
L'invention porte sur le rôle fonctionnel significatif de plusieurs gênes C. elegans et les produits géniques correspondants dans les processus de division et de prolifération cellulaires pouvant être identifiées par interférence médiée par ARN (RNAi)et sur l'identification et l'isolement des orthologues fonctionnels desdits gènes y compris l'ensemble de leurs dérivés biologiquement actifs. L'invention porte également sur l'utilisation desdits produits géniques (y compris leurs orthologues) dans le développement ou l'isolement d'agents antiproliférants et en particulier pour des essais de criblage appropriés, ainsi que pour le diagnostic et le traitement des maladies proliférantes.
Echeverri Christophe
Goenczy Pierre
Hyman Anthony
Jones Steven
Kirkham Matthew
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cenix Bioscience Gmbh
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