Process for preparation of 7-alkoxy-3- bromomethylcephems

Details Process for preparation of 7-alkoxy-3- bromomethylcephems Process for preparation of 7-alkoxy-3- bromomethylcephems

C - Chemistry, Metallurgy

07

D

260/102

C07D 501/24 (2006.01) A61K 31/54 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/16 (2006.01) C07D 501/18 (2006.01) C07D 501/20 (2006.01) C07D 501/57 (2006.01) C07D 501/60 (2006.01) C07D 501/32 (2006.01) C07D 501/34 (2006.01)

Patent

CA 1108121

Abstract of the Disclosure 7-Alkoxy-3-bromomethyl-3-cephems are provided by a novel process comprising reacting a 3-methylenecepham with an alkali metal salt of a lower primary alcohol in the presence of a positive brominating agent at a temperature ranging from -80°C. to 0°C. The 3-bromomethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics. X-4395

271404

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