C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/278.1, 260/3
C07D 403/12 (2006.01) C07D 233/48 (2006.01) C07D 295/12 (2006.01)
Patent
CA 1069514
ABSTRACT OF THE DISCLOSURE This invention relates to novel substituted 4-phenyl imidazolines having interesting pharmacological properties. These compounds have the general formula Image I (wherein R1 represents a fluorine, chlorine or bromine atom or a methylgroup; R2 and R3, which may be the same or different, each represents a hydrogen or chlorine atom or a methyl group; R4 represents a hydrogen atom or a methyl or ethyl group; and R5 and R6, which may be the same or different, each represents a methyl or ethyl group or an alkoxyalkyl group containing from 2 to 4 carbon atoms, or taken together with the nitrogen atom to which they are attached, R5 and R6 form a pyrrolidino, piperidino, morpholino, hexamethyleneimino, piperazino or N-methylpiperazino ring, and pharmaceutically acceptable acid addition salts thereof. In particular they have been found to exhibit blood-flow enhancing and thrombocyte-agglomeration inhibiting activities. Processes for the preparation of the novel compounds are described and exemplified and examples of pharmaceutical compositions containing the novel compounds are given.
254445
Haarmann Walter
Koppe Herbert
Kummer Werner
Reichl Richard
Stahle Helmut
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