Process for the preparation of a therapeutically active...

Details Process for the preparation of a therapeutically active... Process for the preparation of a therapeutically active...

C - Chemistry, Metallurgy

07

C

260/598.7

C07C 85/147 (1980.01)

Patent

CA 1048061

A B S T R A C T A process for the preparation of N-cyclohexyl-N-methyl-(2-amino- 3,5-dibromobenzyl)-amine which has the formula Image and acid addition salts thereof, comprising reacting 2,4-dibromo-6-[(N-methyl- N-cyclohexyl)-aminomethyl]-benzoic acid, which has the formula Image with hydrazoic acid (HN3) which reacts in statu nascendi by the addition of a salt of hydrazoic acid to a solution of an inert organic solvent, a strong acid and said 2,4-dibromo-6-[N-methyl-N-cyclohexyl)-aminomethy]-benzoic acid at a temperature of 35-100°C to thereby form N-cyclohexyl-N-methyl-(2- amino-3,5-dibromobenzyl)-amine. The product, otherwise known as bromhexine and its acid addition salts are therapeutically useful, particularly as cough relieving agents.

209447

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