C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/328
C07D 335/06 (2006.01)
Patent
CA 1138881
Abstract Novel benzothiopyran derivatives of the general formula Image in which R is free, esterified or amidated carboxyl or free or etherified hydroxymethyl, Ph is 1,2-phenylene which contains the group R-CO-NR3- and can be substituted, X is a group of the formula -CO-CR1=CR2, in which R1 and R2 independently of one another are hydrogen, acyl or a sub- stituted or unsubstituted hydrocarbon radical or a hetero- analogue thereof or together are 3-membered to 5-membered lower alkylene, and R2 can also be free or etherified hydroxyl or hydroxyl esterified by an organic carboxylic aicd, and R3 is hydrogen or lower alkyl, possess anti- allergic properties and can be used as medicaments. They are prepared, for example, by reacting a compound of the general formula Image (II) in which Ph, R3 and X are as defined, or a salt thereof, with one equivalent of an oxalic acid, which can be func- tionally modified, or a salt thereof.
321506
Fetherstonhaugh & Co.
Novartis Ag
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