C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/105.1
C07D 501/06 (2006.01) A61K 31/545 (2006.01) C07D 501/36 (2006.01)
Patent
CA 1057740
ABSTRACT 3-Heterothio[alkoxycarbonyl and alkoxythiocarbonyl)- thioacetyl]cephalosporin derivatives which have the formula Image wherein R1 is hydrogen, lower alkyl, phenyl, furyl or thienyl; R2 is lower alkyl or phenyl-lower alkyl; R3 is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, a salt forming ion, or -CH2-O-?-R; R is lower alkyl, phenyl or phenyl-lower alkyl; Z is O or S; R4 is a nitrogen and/or sulfur or oxygen containing heterocyclic ring system selected from the group consisting of oxadiazole, thiazole, tetrazole and thiadiazole and in addition, when Z is O, isoxazole, isothiazole and 1- oxopyridine and when Z is S, triazole and thiatriazole, and lower alkyl substituted analogs of said heterocyclic rings; are useful as antibacterial agents.
229638
Breuer Hermann
Treuner Uwe D.
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