C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/305, 260/352
C07D 233/44 (2006.01) C07C 281/18 (2006.01) C07D 233/52 (2006.01)
Patent
CA 1064503
Title: Amidino-hydrazone derivatives. Abstract of the Disclosure The invention relates to novel amidino-hydrazone deriv- atives of the general formula: Image I in which the dotted lines mean one extra bond starting from the (guanidine-)carbon atom to one of the adjacent nitrogen atoms, and A stands for methylene, ethylene, propylene or butylene, which groups may optionally be substituted with alkyl (1-4 c), B stands for hydroxy, alkyl (1-4 C), alkylthio or alkoxy (1-4 C), halogen, trifluoromethyl, nitro, amino, hydroxymethyl, acyloxy or an alkylenedioxy group, n is the number 0, 1, 2, 3, or 4, R1, R4 and R5 represent hydrogen or alkyl (1-4 C), with the proviso that one of them is absent in view of the presence of the double bond, R2 and R3 stand for hydrogen, alkyl (1-4 C), aralkyl, aryl, hydroxy or amino, with the proviso that R2 + R3 together may also represent a saturated or unsaturated alkylene group of 2 carbon atoms, or as well as the pharmaceutically acceptable acid addition salts thereof, having valuable, antihypertensive and antithrombosis activities.
228174
Bruins Antonius H.n.m
Panneman Harm J.
Akzona Incorporated
Na
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