Process for preparing substituted guanidines

Details Process for preparing substituted guanidines Process for preparing substituted guanidines

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/64 (2006.01)

Patent

CA 1068715

ABSTRACT OF THE DISCLOSURE Pharmacologically active compounds of the formula: Image wherein R1 represents Het-CH2S(CH2)2- wherein Het is imidazole, optionally substituted by (C1-4) alkyl, and R2 is hydrogen or (C1-4) alkyl. The compounds can be in the form of a hydrate, a pharmaceutically acceptable acid addition salt or a hydrated salt thereof. The compounds are histamine H2-antagonists and are useful as inhibitors of gastric acid secretion, as anti- inflammatory agents and as agents which act on the cardiovascular system.

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