Non-activating polyelectrolytes for separation of blood...

Details Non-activating polyelectrolytes for separation of blood... Non-activating polyelectrolytes for separation of blood...

C - Chemistry, Metallurgy

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C08F 222/06 (2006.01) C07K 14/755 (2006.01) C08F 8/30 (2006.01) C08L 35/00 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1133191

ABSTRACT OF THE DISCLOSURE Blood coagulation factors such as Factor VIII are separated from admixture with other blood proteins without producing activation of said coagulation factor by contacting with a water-insoluble, cross-linked polyelectrolyte copolymer of (a) C2-18 unsaturated monomer and (b) C4-12 unsaturated polycarboxylic acid or anhydride, in which 2-100% of the carboxyl sites are substituted with amine-imides and substantially all the free anhydrides are blocked with alkoxy- alkylamine to form alkoxyalkylimide units.

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