Indolyloxy-aminopropanol derivatives

Details Indolyloxy-aminopropanol derivatives Indolyloxy-aminopropanol derivatives

C - Chemistry, Metallurgy

07

D

260/319

C07D 209/04 (2006.01) C07D 209/12 (2006.01) C07D 209/30 (2006.01) C07D 209/42 (2006.01)

Patent

CA 1098909

100-4851 INDOYLOXY - AMINOPROPANAOL DERIVATIVES Abstract of the disclosure The compounds of formula I Image I wherein R is a group Image , wherein A is alkylene of 2 to 5 carbon atoms, X is a bond, oxygen or sulfur, R3 is hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, halogen of atomic member of from 9 to 35, cyano, carbamoyl or a group NHCORd, wherein Rd is alkyl of 1 to 4 carbon atoms, and R4 is hydrogen and, when R3 is alkoxy of 1 to 4 carbon atoms, R4 additionally may be alkoxy of 1 to 4 carbon atoms or, when R3 is halogen of atomic number of from 9 to 35, R4 additionally may be halogen of atomic number of from 9 to 35 either 100-4851 i) R1 is hydrogen or methyl and R2 is cyano, CONRaPb, COORc or CH2Ore, wherein Ra, Rb, Rc and Re independently are hydrogen or alkyl of 1 to 4 carbon atoms, or ii) either R1 is methyl and R2 is halogen of atomic number of from 17 to 35 or R1 is halogen of atomic number of from 17 to 35 and R2 is hydrogen or methyl, with the provisos that a) X is separated from the nitrogen atom of the 3- amino-2-hydroxypropoxy chain by at least 2 carbon atoms, b) when X is a bond, R3 is other than hydrogen and c) when R2 is cyano, R additionally may be alkyl of 3 to 7 carbon atoms, are useful as .alpha.- and .beta.-adrenoceptor blocking, anti- arrhythmic and antihypertensive agents and as inhibitors of metabolic effects of emotional stress.

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