Cephalosporin-type antibiotics and process for producing the...

Details Cephalosporin-type antibiotics and process for producing the... Cephalosporin-type antibiotics and process for producing the...

C - Chemistry, Metallurgy

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C07D 501/04 (2006.01) A61K 31/545 (2006.01) C07D 501/24 (2006.01) C07D 501/36 (2006.01) C07D 501/40 (2006.01) C07D 501/42 (2006.01) C07D 501/46 (2006.01) C07D 501/48 (2006.01) C07D 501/54 (2006.01) C07D 501/56 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1072950

M-6-14536C/75 ABSTRACT OF THE DISCLOSURE A cephalosporin compound represented by the formula (I) or (I') Image (I) Image (I') wherein R1 represents a phenyl group, a 2-thienyl group or a phenoxy group; R2 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may be substituted with a phenyl group, an alkoxy group having 1 to 4 carbon atoms or a halogen atom, or a phenyl group which may be substituted with one or two groups selected from the group consisting of a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may be substituted with a monoalkylamino group having 1 to 4 carbon atoms in the alkyl moiety thereof, a dialkylamino group having 1 to 4 carbon atoms in each alkyl moiety thereof, a halogen atom or a phenyl group which may be substituted with one to three groups selected from the group consisting of a halogen atom, a nitro Abstract continued: group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R4 represents an alkyl group having 1 to 4 carbon atoms; A has up to 15 carbon atoms and represents a straight or branched chain alkylene group, a straight or branched chain alkenylene group, a straight or branched chain alkadienylene group or a phenylene group, and n is 0 or 1; or the salt thereof; and a process for preparing the same. These novel cephalosporin compounds have excellent anti- microbial activity and low toxicity.

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