Physiologically active derivatives of esterastin and...

Details Physiologically active derivatives of esterastin and... Physiologically active derivatives of esterastin and...

C - Chemistry, Metallurgy

07

D

260/368.5

C07D 305/12 (2006.01)

Patent

CA 1155862

TITLE OF INVENTION New physiologically active derivatives of esterastin and production thereof ABSTRACT OF THE DISCLOSURE Three, new physiologically active derivatives of esterastin are now provided, which inhibit the activity of esterase similarly to the parent esterastin and further exhibit a higher inhibiting activity against cholesterol esterase than the parent esterastin. These three new derivatives are tetrahydroesterastin which is produced by catalytic hydrogenation of esterastin; 3,5-di-hydroxy-2-hexylhexadeca-7,10-dienoic 1,3-lactone which is produced by alkaline hydrolysis of esterastin; and 3,5-di-hydroxy-2-hexylhexadecanoic 1,3-lactone which is produced either by alkaline hydrolysis of said tetrahydroesterastin or by catalytic hydrogenation of the product of the alkaline hydrolysis of esterastin. - 1 -

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