C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/254, 260/466
C07D 263/28 (2006.01) C07C 275/34 (2006.01) C07C 275/42 (2006.01) C07D 239/80 (2006.01) C07D 239/96 (2006.01)
Patent
CA 1063112
ABSTRACT OF THE DISCLOSURE Described herein are novel hydroxylpolyhaloisopropyl- substituted ureido compounds exhibiting useful anti- hypertensive activity, processes for their preparation and pharmaceutical compositions containing these compounds. The ureido-compounds are selected from phenyl ureas, oxazolines and quinazolines represented by the formula: Image and the pharmaceutically acceptable salts of the oxa- zolines and quinazolines, where Z represents Image , Image or, together with X2, the grouping Image in which R1 is ethylene or substituted ethylene and R and R2 represent other specified sub- stituents and wherein one of X2 and X4 is the hydroxy- polyhaloisopropyl grouping Image in which Y inde- pendently represents hydrogen chlorine or fluorine while the other of X2 and X4, as well as X3, X5 and X6, re- present other specified substituents. -1-
240512
Na
Scherico Ltd.
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